To understand INNO-EXOMA® and its function, we need to delve into the world of exosomes first.

Exosomes play a crucial role in extracellular communication and tissue regeneration. They are tiny vesicles released by cells in charge of the exchange of amino acids, proteins, growth factors, anti-inflammatory cytokines, and genetic material between cells.

They travel through intercellular spaces to deliver their bioactive cargo to target cells, where it is interpreted as pertinent information that serves as guidelines to enhance cell function and initiate crucial physiological processes. This ultimately leads to outstanding regenerative capabilities that enable tissues to heal themselves.

Exosomes possess two exclusive characteristics that elevate them as the most effective nanocarriers:

1. NANO PRECISION Ranging from 30 to 150 nanometers, exosomes stand as the tiniest type of extracellular vesicles, ensuring precise delivery.

2. GUARDIANS OF CARGO Wrapped in a lipid bilayer, exosomes shield their cargo, seamlessly integrating into cells and releasing bioactive substances. EXOSOMES play a vital role in several physiological processes. They promote cell proliferation, migration, and differentiation, ultimately boosting the synthesis of key tissue components, leading to tissue repair and regeneration.

They regulate inflammation, promote collagen synthesis, and enhance tissue regeneration

SKIN AGING: Prevents and reverses all signs of skin aging. • SKIN CONDITIONS: Acne, oily and dry skin, uneven pigmentation, couperose, etc. •

HAIR LOSS: Improves scalp microenvironment and regenerates hair bulbs click here for more info.

3 sessions at 3-4 weeks apart. This treatment cycle can be repeated every 6 months if you require.

While the remarkable effects of INNO-EXOMA® EXO-SKIN endure over the long term, it is important to note that these outcomes, like many physiological processes, require a gestation period before manifesting. Typically, the effects of INNO-EXOMA® EXO-SKIN become apparent one month after the f irst session, but this can vary from one patient to another.

INNO-EXOMA® EXO-SKIN

INNOAESTHETICS’ R&D department has dedicated two years of research to creating a synthetic exosome molecule that replicates the mechanism of action of cell-derived exosomes. This effort led to the development of a breakthrough biotechnology called NARBEXTM.

NARBEX (Non-Animal Regenerative Bioengineering Exosome) technology enables the crosslinking of peptide chains to create a molecule that emulates the signaling biological qualities and capabilities of mesenchymal cell-derived exosomes. It not only matches their properties but also enhances them.

Our molecule replicates the active part of the proteins contained in cell-derived exosomes to enrich and activate skin cells. These exosome-like molecules establish intercellular communication bridges, igniting a cascade of processes that restore essential skin elements and deeply regenerate and rejuvenate the skin tissues.

Innoaesthetics’ exosome-like molecule has been created thanks to a cutting-edge bio technology called NARBEX™ (Non-Animal Regenerative Bioengineering Exosome), which allows the assembly of peptide chains in a specific way to replicate the active protein part of a biological exosome.

Each vial of INNO-EXOMA® EXO-SKIN contains millions of our exosome-like molecules. Thanks to its intensive regenerative effects, INNO-EXOMA® EXO-SKIN is a versatile product that enhances skin health, targeting the specific needs of each individual. It is beneficial for all skin types and can improve most skin issues.

It also contains:

4 Amino Acids for collagen production & tissue repair

3 Amino Acids for antioxidant action

5 Peptides as Biochemical Mediators

2 GAGs for Hyaluronic Acid production

Mannitol as Free Radical Scavenger

Do not have/use (in the area to be treated) one week prior to your appointment, any products containing topical retinoids (Vitamin A, Retinol, Retin A etc), blood thinning agents (this includes aspirin, fish oil, Omega-3, Vitamin E), and avoid electrolysis, depilatory creams, waxing, sunburn/windburn, cuts or skin abrasions.

To minimise bleeding, please avoid drinking alcohol for 2-3 days prior to your treatment.

Yes , but not during an active flare up. This treatment can significantly reduce inflammation in the skin.

Yes, but not severe acne

SAFETY AND ETHICS AT THE CORE.

Since cell-derived exosomes contain genetic information, their use is restricted to regenerative medicine for safety reasons. INNOAESTHETICS’ exosome-like molecule is 100% synthetic, not derived from any human, animal, or vegetable cells. It offers high tolerance and poses no health nor allergy risks.

INNO-EXOMA® EXO-SKIN is formulated and manufactured in our production plant, complying with the strict European standards and regulations.

Yes. The efficacy of INNO-EXOMA® EXO-SKIN was tested in a clinical trial yielding highly satisfying results for patients.

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Wait at least 2 weeks after.

Yes! If you would like to improve scars, and skin laxity/sagging skin, the addition of radiofrequency therapy to microneedling treatments can give you dramatically better results. The combination of the two therapies helps further stimulate collagen production, giving your skin a healthier, firmer, rejuvenated appearance.

The cost of RF is reduced by 50% when combined with microneedling.

What makes RF plus microneedling better is that the microneedling part of the procedure creates numerous minuscule pinpricks in the skin. These pinpricks serve as microscopic channels for the flow of radiofrequency energy, which is applied subsequently. As a result, not only are the skin’s natural healing responses evoked, but collagen production is stimulated to give you smoother, tighter, younger-looking skin.

An added advantage of the microneedling plus RF combination is that it is less aggressive than deep chemical peels and laser skin resurfacing. This means you can achieve noticeable improvements in the appearance of your skin with a shorter recovery time, usually less than 5 days. Most clients experience only minor redness and dryness after microneedling plus RF and can return to work immediately after the treatment. You should be aware that you will require multiple treatment sessions of RF and microneedling for optimum results.

You can read more on RF here: Heat-Wave Face and Heat-Wave Body.

Exosomes enhance cell function and promote tissue repair. They deliver precise signals to stimulate regeneration and help reduce scars.

To reduce and improve the appearance of scars, stretch marks, acne scarring and chicken pox scars you need to treat the skin at the dermis level to kickstart the body's healing process. Microneedling combined with radio frequency is a good combination when treating scarring. The tiny micro-needles create small punctures on the top layer of the skin and penetrate the dermis at a depth from around 1.5mm. The wounds “traumatize” the skin and trigger the body’s natural response of creating more collagen and elastin to heal the wound, improve texture and firmness, and reduce scars and stretch marks. It is important to have realistic expectations when treating scarred skin.

When it comes to your skin, there are 3 different layers: the epidermis (outer), the dermis (middle), and the subcutaneous/hypodermic (deepest). Stretch marks occur in the dermis when the connective tissue is “stretched” beyond its power of flexibility. As it’s stretching, the collagen weakens and the normal production to keep the skin youthful is disrupted. What is left behind is the appearance of lighter skin, some redness at first, as well as what may look like bruising within the mark. The natural healing process of the skin happens in three phases: 1) Inflammation – Once skin is pierced, it triggers the response from the immune system to naturally disinfect wounds, remove debris, increase blood flow, and create new tissue. 2) Proliferation – The wound starts to rebuild itself with new cells and temporary collagen and elastin, as well as a new network of blood vessels. 3) Remodeling – The collagen produced in Phase 2 is replaced by even stronger collagen, allowing the skin to contract and create a tightening effect on the skin.

If you want to combine topical products alongside your microneedling, Vitamin E is an antioxidant known for its anti-ageing and skin-regenerating benefits.​

Old stretchmarks often need a longer course of treatment, especially if they are silver in colour.

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Not just microneedling!

Consultation

Double cleanse

Gentle superficial chemical Peel lowering skin PH to 3 or 1.5 is applied.

INNO-EXOMA® EXO-SKIN is applied to the skin.

Microneedling with our medical-grade needling device at varied depths depending on skin concern and area.

Bio Cellulose Mask

Protective serum (and SPF if applicable).

Micro-needling is a process called collagen induction therapy (CIT). CIT is the skin’s ability to repair itself.

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During this revolutionary procedure, a small, electronic instrument containing tiny needles moves over the skin to create thousands of microscopic channels in both the epidermis and upper dermis of the skin. The body responds to this controlled wound healing the same way it would to an injury by releasing powerful growth factors type 1 and type 3 collagen. By stimulating the cells a natural healing response is an increase in collagen and elastin produced and the appearance of fresher, newer-looking skin.

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The size, depth and angle of the needles mean no blood is drawn and it is a comfortable treatment.

The needle length is only 0.25mm-0.5mm (deeper for scars etc) and can be altered to make the treatment more comfortable around more sensitive areas and areas that need deeper penetration.

It is especially effective for addressing the visible signs of ageing as well as sun damage, scarring, slackened skin, stretch marks, uneven skin tone and dilated blood vessels.

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Furthermore, these "micro-channels" allow for deeper penetration of pharmaceutical solutions, resulting in higher efficacy.

At Westfield Clinic we use INNO-EXOMA® EXO-SKIN or FILLMED NCTF® 135HA and M-HA®10

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There have been many studies on the effectiveness of microneedling, some of which you can read here.

Award-winning imedpen® x

There may be some very mild discomfort but the treatment is generally very well tolerated.

Microneedling should not cause blood spots.

It is not advised to use numbing cream pre-treatment, as numbing cream causes vasoconstriction of superficial vessels.

• Your skin may look a little pink for a few hours after. When working deeper in the skin or for those with very sensitive skins this may last up to 48hrs. However as Exosomes are excellent in reducing inflammation in the skin we tend to find that skin is much less pink than when having microneedling without exosomes.

• Do not use any Alpha Hydroxy Acids, Beta Hydroxy Acid, Retinol (Vitamin A), Vitamin C (in a low pH formula) or anything perceived as ‘active’ skincare for at least 7 days post-treatment.

• Avoid extended periods in the sun and apply an SPF of 30 or higher when you leave the house - for 7 days.

• Do not go swimming for at least 48 hours post-treatment.

• No exercising or strenuous activity for the first 24 hours post-treatment. Sweating and gym environments should be avoided as they can expose you to dirt and bacteria which may cause adverse reactions.

• Do not apply makeup to the skin for 48-72 hours

• If possible, avoid taking anti-inflammatory medications or supplements for at least one week after microneedling. Some products to avoid include NSAIDs, such as Ibuprofen, or ginger, turmeric, fish oil, vitamin E, arnica and bromelain supplements (Inflammation is a crucial part of the skin healing process and taking anti-inflammatories will slow the rate at which your skin heals).

External products after microneedling (such as serums) work best when applied within the first 24 to 48 hours. After that, all the microchannels that were made are closed. When choosing skincare products to apply after microneedling opt for products with a high purity of ingredients, low-irritants and hydrating ingredients (Hyaluronic Acid is amazing)​

In all tests and clinical studies performed, no significant side effects have been found in using Exosomes.

After microneedling, your skin will likely turn a little pink, which generally lasts a few hours but may be longer, some people can have pink skin for up to 3 days but this is unusual.

Your skin might look a little blotchy or be a little swollen.

Small, minor bruising, especially around areas of thin tissue is very rare, but a possibility.

Avoid microneedling if you wish to attend an event within 48 – 72 hours post-treatment. Avoid microneedling if you are feeling unwell or under the weather.

INNO-EXOMA® EXO-SKIN have no known immunological activity, so there are no specific contraindications.

Contra-indications for microneedling can include: Botox or Fillers in the treatment area are to be avoided 2 weeks prior.  Allergies to local anaesthetic (if using) or ingredients in mesotherapy products.  Pregnant or breastfeeding.  Anti-coagulant therapy – increases potential for bleeding - coagulation status should be checked to confirm normal clotting/bleeding profile.  Haemophiliacs.  History of keloid scarring.  History of radiation therapy within the application area (6 months post chemo & radiotherapy).  Raised moles or warts.  Skin cancers – melanoma.  Skin infections including any bacterial, viral, fungal, or herpetic infection.  Wounded, sunburned, excessively sensitive skin.  Inflammatory acne within the application area.  Uncontrolled diabetes.  Active eczema, psoriasis or inflamed/severe rosacea in the area.  Oral retinoids (Roaccutane) used within 6 months prior to treatment.  We recommend carrying out a patch test for Fitzpatrick skin types 4 or above.  Unrealistic expectations ​ Medications - If you’re taking medications such as Accutane, antibiotics, antidepressants, or medications that cause photosensitivity or high blood pressure, please consult before commencing microneedling. ​ Cosmetic treatments - If you’re undergoing cosmetic treatments including chemical peels, laser, cosmetic surgery, filler injections, or cosmetic surgery, it’s necessary to wait until your skin fully recovers before commencing microneedling. Make sure to check with your medical professional before you start microneedling to make sure it will not interfere with any of your cosmetic procedure results.

Yes, it will rejuvenate hair growth on the scalp, and can be used on the back of hands aswell as body areas.

Polynucleotides work at cellular level to help cellular repair and regeneration, enhance skin texture and resilience. Polynucleotides are more focused on hydration and structural support. They are ideal for those experiencing dry skin, loss of elasticity, or needing intensive skin repair due to environmental damage. Polynucleotides are delivered via multiple small injections to the skin surface, you can read more about the treatment here.

• Deep Hydration: Addressing dry, dehydrated skin

• Improved Elasticity: Counteracting sagging skin

• Skin Repair: Assisting in the recovery of sun-damaged skin and reducing post-inflammatory hyperpigmentation

Exosomes, the body’s cellular messengers, harness the power of intercellular communication to rejuvenate and repair skin at a molecular level. Exosomes are particularly suited for individuals dealing with advanced aging signs, pigmentation issues, and skin texture concerns. They offer a comprehensive approach to skin rejuvenation by targeting multiple skin layers and promoting holistic regeneration.

• Anti-Aging: Reducing the appearance of fine lines and wrinkles

• Skin Brightening: Evening out skin tone and addressing hyperpigmentation

• Healing and Repair: Accelerating the healing process for acne scars and other skin injuries

We recommend alternating polynucleotide and exosome treatments for optimal results, as they address different aspects of skin rejuvenation.

Exosomes can enhance the effects of polynucleotides by improving cellular communication, while polynucleotides provide the structural support for regeneration

Yes, INNO-EXOMA is vegan-friendly because it uses 100% synthetic exosomes, meaning it is free from animal or plant sources