With both Vitaran and Plenhyage XL, a course of 3 spaced 3-4 weeks apart is recommended..

The timeline for visible results from Polynucleotide treatments can vary, depending on individual skin types and the specific concerns being addressed. Generally, clients begin to notice improvements within a few weeks after the initial treatment.

The full effects, however, typically become more apparent over the course of several months. This gradual progression is due to the nature of polynucleotides, which work by stimulating the body’s natural processes of collagen and elastin production, as well as enhancing cellular regeneration.

As these processes take time, the skin’s appearance improves incrementally. Most clients observe a noticeable difference in skin hydration, texture, and elasticity within the first month, with continued improvements in firmness and a reduction in fine lines and wrinkles over the following months. It’s important to note that multiple treatment sessions may be necessary to achieve optimal results, and these should be spaced out. The longevity and effectiveness of the treatment are also influenced by factors such as lifestyle, skin care routine, and overall health, making it essential to follow post-treatment care instructions and maintain a healthy lifestyle for lasting results.

They can be used across all areas of the face, neck, decolletage and hands. These injectables work to regulate the biological process of living cells and repair the skin’s natural barrier.

Polynucleotides are also suitable for under the eyes, which is great, as some skin boosters cannnot be used in this area, due to containing Hyaluronic acid which can increase pufinesss under the eye area.

Plenhyage XL Strong is not suitable for under the eyes, on the lips, or on the forehead, but Vitaran is suitable for all these areas.

This is the Decolletage Area:

You will have visible small blebs on the skin for a few hours after treatment. These will likely have dispersed by the next day and you can go about your normal routine. Some may continue for a maximum of 3 days although rare and some minor bruising is possible.

You can expect the rejuvenating effects to last for approximately 6-9 months after your course providing you with long-lasting benefits. Some people benefit up to 12 months.

Pre-Treatment Advice:

Please arrive with no make-up on to reduce the risk of infection, and ensure you are well hydrated.

To reduce risk of bruising, swelling, and irritation, please avoid the following before your treatment:

24 hours before:

o Alcohol (increases bruising and swelling).

o Limit caffeine (may increase sensitivity).

3–5 days before:

o Blood-thinning medication (aspirin, ibuprofen, naproxen) – unless prescribed by your doctor.

o Supplements that increase bruising (fish oils, vitamin E, garlic, ginkgo biloba, ginseng, St John’s Wort).

5-7 days before:

o Active skincare (retinol, retinoids, glycolic/salicylic/lactic acid, strong vitamin C).

2 weeks before:

o Chemical peels, microneedling, or laser treatments.

o Facial hair removal (waxing, threading, depilatory creams, bleaching).

General health:

o Do not attend if you have active skin infections, cold sores, or inflamed acne.

o Treatment is not suitable if you are unwell, on antibiotics, pregnant, or breastfeeding.

Yes you can both Vitaran and Seventy Hyal in the same area, during the same session to target a variety of concerns! ie you could have 2ml of Vitaran and 2ml of Seventy Hyal, placed in specific areas ie Viatarn to the pigmented areas, where skin needs repairing, or under the eyes, and Seventy Hyal to the areas that need hydration, or with BAP technique (5 specific points either side of the face to deeply hydrate).

For Ageing/Mature Skin:

Loss of suppleness

Fine lines & wrinkles

Lack of hydration

Crepey or sagging skin

Free radical damage e.g sun damage

For Younger Skin:

Lack of hydration

Skin texture

Sebum overproduction

Inflammation

Early collagen & elastin loss

Free radical damage e.g sun damage

Profhilo treatments however, should be completed first (course of 2) before polynucleotides are started.

NO, the key ingredients in skin boosters is usually hyaluronic acid and amino acids. These work to add volume, hydration and a gentle filling effect. However, they do not have a regeneration action and therefore results are limited to a few months.

With polynucleotides, the active ingredient is purified PDRN. This works to boost fibroblast production, induces tissue repair processes, reduces inflammatory process, regulates melanogenesis, promotes hydration, and promotes myofibroblasts.

It won’t give you the ‘instant volume’ that dermal fillers create, but it WILL give you a natural result through regeneration of the actual tissues.

Rather than giving skin a surge in collagen and elastin, or ‘plumping’ the skin with carefully placed temporary products, polynucleotides are catalysts in the regeneration of fibroblasts – the main cells within the skin’s structure. The product itself is absorbed by the body fairly rapidly, having activated new cell production. Of course, we continue to age, but the clock has quite literally been turned back in your treated areas.

NO, dermal fillers add volume to the skin, whereas polynucleotides stimulate regeneration.

Rather than ‘plumping’ the skin with carefully placed temporary products, polynucleotides are catalysts in the regeneration of fibroblasts – the main cells within the skin’s structure. The product itself is absorbed by the body fairly rapidly, having activated new cell production. Of course, we continue to age, but the clock has quite literally been turned back in your treated areas.

Polynucleotides work at cellular level to help cellular repair and regeneration, enhance skin texture and resilience. Polynucleotides are more focused on hydration and structural support. They are ideal for those experiencing dry skin, loss of elasticity, or needing intensive skin repair due to environmental damage.

• Deep Hydration: Addressing dry, dehydrated skin

• Improved Elasticity: Counteracting sagging skin

• Skin Repair: Assisting in the recovery of sun-damaged skin and reducing post-inflammatory hyperpigmentation

Exosomes, the body’s cellular messengers, harness the power of intercellular communication to rejuvenate and repair skin at a molecular level. Exosomes are particularly suited for individuals dealing with advanced aging signs, pigmentation issues, and skin texture concerns. They offer a comprehensive approach to skin rejuvenation by targeting multiple skin layers and promoting holistic regeneration. Exosomes are delivered via microneedling, you can read more about the treatment here.

• Anti-Aging: Reducing the appearance of fine lines and wrinkles

• Skin Brightening: Evening out skin tone and addressing hyperpigmentation

• Healing and Repair: Accelerating the healing process for acne scars and other skin injuries

We recommend alternating polynucleotide and exosome treatments for optimal results, as they address different aspects of skin rejuvenation.

Exosomes can enhance the effects of polynucleotides by improving cellular communication, while polynucleotides provide the structural support for regeneration

VITARAN is a 100% quality-controlled polynucleotide injectable derived from purified trout DNA, with one of the highest quantity of polynucleotides on the market. While it shares the same 20mg per 1ml as other polynucleotide treatments such as Plinest, and Nucleofill, VITARAN’s 2 syringes per box ensures that it has industry-leading levels of polynucleotide.

PLENHYAGE XL STRONG conatins 25 mg/ml per 1ml. The high molecular weight polynucleotide chains in PLENHYAGE XL Strong possess biochemical characteristics that make them highly viscoelastic and capable of binding and orienting a considerable quantity of water molecules in space. The water molecules are mainly retained at the level of the hydrophilic groups of the phosphorylated sugars of the individual nucleotides. Excellent for body areas e.g. hands, thighs and knees.

BOTH

CE-Marked – Both CE-marked treatments. This CE mark means that the products meet strict EU safety, health and environmental protection requirements.

Tissue Repair – As bio-stimulating injectables, works on a cellular level to repair and improve skin quality from the inside out.

Anti-Inflammation – In comparison to other injectable treatments, both are less likely to cause inflammation in the injection area. VITARAN in particular is suitablefor sensitive skin

Stimulated Collagen & Elastin – Both stimulate fibroblast cells, which aid in the production of both collagen and elastin. Helping to stimulate both restoration and rejuvenation of the skin.

Vitaran → Fine lines and wrinkles, mild to average sun-damage, under-eye rejuvenation (dark circles, fine lines) and lips. General treatment for all skins, and suitable for sensitive skin.

Plenhyage XL Strong → Deep wrinkles, scarring, advanced sun-damage, melasma, stretch marks, post-surgery healing, and body areas (neck, décolleté, knees, hands). Intensive regeneration in larger or tougher areas. Not suitable for eyes, lips or forehead.

Yes, PN are great for all the usual skin concerns we see on the face as well as targeting scars, stretcmarks and loose skin on the body.

We recommend Plenhyage XL Strong on the body when targeting stubborn pigmentation, scars, stretchmarks, and loose skin.

The amount of PN required depends on the size of the area. For example, 2ml will cover an area the size of 2 hands.

With 41+ years of scientific research and development, 36 + years of medical application, 1.8 million uses and no adverse or allergic reactions, Polynucleotides are the gold standard in true skin regeneration. Utilising filtered, ultra purified and sterilised natural DNA fractions, this injectable serum offers some serious benefits and incredible, visible results.

With over 90 clinical trials and a proven track record in tissue and cartilage regenerative medicine, the evidence for the power of Polynucleotides is undisputed in both the medical and aesthetic fields. Once filtered and ultra-purified, natural DNA fractions initiate your body’s natural fibroblast production, resulting in increased collagen (average 47% in 23 days) and a thicker, healthier epidermis (average 52% in 23 days).

Thanks to polynucleotides’ antioxidant properties, inflammation is reduced and youthful volume and hydration ARE restored. The list of applications are endless, but key uses include;

• Skin revitalisation to combat signs of ageing

• Rehydration for dull skin at any age

• Hyperpigmentation

• Acne

• Atrophic scarring (including post acne scaring)

• Preparation and recovery pre/post procedures. Laser skin rejuvenation treatment results are greatly enhanced from pre-treating with polynucleotides

• Rosacea

• Elastosis

• Stretch marks

• Deep lines & wrinkles

• Alopecia/hair loss

Immediately After Treatment

For the first 48 hours post-treatment:

Avoid touching the treatment area. The small 'blebs' usually dissapear within a few hours.

If necessary, apply a cold compresses like an ice pack wrapped in a clean, soft cloth to reduce swelling and discomfort. Make sure to limit application to 10-15 minutes at a time.

Stay hydrated to aid the body’s natural healing process.

Ensure you have a clean, fresh pillow case on your bed following treatment.

First Few Days +

As the skin begins to settle and heal:

Avoid sun exposure. Use a high-SPF sunscreen (30+) to protect your skin from harsh sunlight.

Avoid direct heat for up to 2 weeks (ie sauna and steam).

Avoid heavy makeup and harsh products containing alcohol, acids, or fragrances.

Avoid strenuous exercise and sweating to reduce bacteria and possible infection at the injection sites.

Long-Term Aftercare

As polynucleotides work on a cellular level, results can take months to appear. Therefore, it’s important to take care of your skin as it heals.

Use a gentle skincare routine with soothing and hydrating ingredients, such as hyaluronic acid (HA) and ceramides.

Avoid any further treatment in the same areas for at least two weeks.

Follow up with your practitioners for any maintenance appointments.

If you notice any unusual signs, such as redness, swelling, or tenderness lasting longer than a few days, signs of infection, severe itching, or difficulty breathing, please immediately seek medical attention.

Not suitable for the following:

• Patients under 18.

• Active acne at the injection sites

• Active Infections (skin)

• Allergy/Hypersensitivity to ingredients (Sodium Polynucleotide if having Polynucleotides)

• Fish allergies

• Pregnant and Breastfeeding mothers

• Body Dysmorphia

• Unrealistic Expectations

• Blood-thinning medication

• Epilepsy

• Papustular Rosacea

• Open Lesions

• Solar Keratosis

• Skin Cancer

• Haemophilia

• Autoimmune diseases

• History of un-absorbable filler or recent filler treatment.

• Patients who are using NSAIDS, platelet aggregation inhibitors, anticoagulants, or immunosuppressants.

• Sarcoidosis granulomatous pathology

• Osler’s endocarditis

• Keloid scarring.

Polynucleotides typically pose a low risk of potential side effects. However, some common side effects may include bruising, or small localised bumps appearing at the injection point. These side effects are normal and generally subside within four to six hours, while small bruising can last up to a week. Infection is always a risk to any injectable treatment, though reduced with infection prevention measures within procedure and appropriate aftercare advice followed.

Minor discomfort may be felt due to the nature of injecting the product into the skin, however numbing cream is optional to reduce any discomfort that may be felt.

Vitaran link to the succesful clinical trial of VITARAN_ClinicalTrials 1.pdf

Plenhyage XL research studies have shown the following effects:

• 115% increase in skin hydration

• Over 50% increase in skin thickness

• 47% increase in collagen production

• 38% increase in skin elasticity

• Reduction in inflammatory redness and improvement in rosacea and acne

• Improvement in acne scarring

• Reduction in pigmentation resulting from sun exposure

Polynucleotides are generally considered hypoallergenic and suitable for all skin types, including sensitive skin. However, as they derive from fish DNA, they are not appropriate for fish allergy sufferers, vegans, or vegetarians.