Cryotherapy Lesion Removal

Cryotherapy is the controlled destruction of unwanted tissue by the precise application of extreme cold. The process is called cryo-necrosis, tissue destruction by freezing. Tissue destruction occurs when cells are low in temperature and at least -80F and ice crystals will form. The ice crystals break the cell membrane, destroy cells organelles and protein matrixes. Water then rushes into the surrounding area causing blistering and disruption of the local blood supply. The innovation of CryoPen® is the direct application of nitrous oxide under high pressure (55 bar).

You will have a consultation, and then a pre-treatment photo will be taken. The area will be cleaned and the lesion will be treated. It usually takes 5-30 seconds to treat each lesion. For example, larger tissue growths such as skin tags and moles take more time. A protective soothing product is be applied and written aftercare advice is given.

Cryotherapy is quicker than other treatments and patients can be in and out in seconds. It requires no anaesthesia and has minimal scarring. There are no limitations on activity except to protect the area from damage or abrasion, they can work, bathe, swim, immediately after the treatment. There are not cuts, bleeding, sutures and risk of infection.

Care should be taken when treating areas with very thin skin and areas where the colour is cosmetically important such as face, ears, scrotum and lateral surface of fingers.

CryoPen® uses disposable cartridges of liquefied N2O to deliver quick, effective cryotherapy treatments to benign skin lesions. Temperature of nitrous oxide is -89°C; it destroys tissue by freezing the intercellular fluid and forming ice shards and crystals that rupture the cell membrane, destroying the cell.

•Versatile treatment options, treats lesions from 1mm to 10mm in size • Fast treatments, treats a 2mm lesion in 10 seconds • Penetrates deeply into lesion (up to 5mm deep) • Safely treats lesions on face and close to eyes • Pinpoint accuracy, treats just the lesion and not healthy surrounding tissue • Can treat longer, with fewer repeat visits • Doesn’t touch skin (no messy buds, cones or apertures) • Enhanced accuracy.

Yes, the CryoPen® is FDA and CE approved. We use the best equipment available... The market-leading CryoPen devices are created and manufactured in Belgium and have been producing cryosurgery medical instruments for the last 24 years.

A typical freeze on viral infections may last from 5 to 10 seconds for a small flat wart and up to 45 seconds for a full thickness plantar wart. For general purposes, most other lesions take about 2 to 30 seconds.

Avoid ANTIHISTAMINES (unless medically prescribed) 48 hours before and 24 hours after treatment (histamine is required in the body, as it is part of the inflammatory response during the skin healing process).Bring your GP/dermatology letter with you which states the skin growth/lesion is non-cancerous or use our fastrack Mole Screening service. Letters should be dated within 12 months.Soften and file down warts and verruccas as much as you can without making the skin bleed the week before.

For warts and verruccas:Using Salactol acid (a combination of salicylic acid and lactic acid) for 4 weeks before your cryotherapy appointment to prepare the wart or verruca, this will allow the freezing treatment to penetrate deeper and act more effectively and will reduce how many freezing treatments you may need. Always follow your Salactol products' recommended guidelines, which will be similar to the following instructions:4 Weeks before your appointment, apply Salactol daily, ideally in the evening. Soak First: Soak the affected area in warm water for up to 20 minutes to soften the skin.Dry Thoroughly: Dry the area completely with your own dedicated towel to avoid spreading the virus.Debride (File): Gently rub the surface of the wart/verruca with a pumice stone or emery board to remove the top layer of dead skin. Note: Do not reuse this file/stone on healthy skin or share it.Apply Salactol: Use the provided applicator to apply the recommended amount directly onto the lesion.Avoid Healthy Skin: Be careful not to apply it to the surrounding healthy skin, as this can cause irritation. You may apply a thin layer of Vaseline around the wart to protect the surrounding skin.Dry and Cover: Allow the Salactol to dry for a few minutes. For plantar warts (foot), cover with an adhesive plaster.Repeat: Repeat this process daily, but stop 2-3 days prior to your appointment.Key ConsiderationsStop if Sore: If the skin becomes too tender, irritated, or starts to bleed, suspend treatment and inform your practitioner.Timeline: Begin this routine 4 weeks prior to your scheduled cryotherapy session.Contraindications: Do not use on the face, near the eyes, in genital areas, or if you are diabetic/have poor circulation.Safety: Salactol is highly flammable; keep away from heat sources. By reducing the thickness of the wart beforehand, the CryoPen treatment is more likely to require fewer treatments.Days before the treatment:Stop applying Salactol product 2-3 days prior to your appointment. It is then recommended to do a pre-treatment softening of the wart or verruca to prepare it for the best possible treatment. The treatment works best when the skin covering these lesions is soft. Follow the steps a few days before treatment.  • Soak the lesion in a bowl of warm, soapy water for 20 minutes.  • With a pumice stone or emery board (nail file), gently scrub the lesion until the skin becomes rough (remember to throw the item away after use). • Please do not scrub so hard that you make the area sore. Discontinue these steps if bleeding occurs. You are not trying to open a wound or cause discomfort. However, the more deeply the jet of nitrous oxide can penetrate, the better the chances of removal are.

No anaesthesia is needed as the extreme cold causes anaesthesia which allows the treatment to be tolerable. ​

Melanocytes are the most sensitive to cold injury. Therefore, they are the most easily damaged with cryotherapy. Darker-skinned patients need to consider the risk of permanent loss of pigment.

Yes, for age 12+ with parental consent and parental presence required at all times.

No its not painful, it you may feel stinging for a few seconds. At a penetration rate of 1mm per 5 seconds, the ice will reach the caudal extent of the lesion after a given amount of time related to the depth of the lesion. It can feel like a ballpoint pen being pushed into the skin from that moment, the patient will experience a pain sensation. There might be a little residual stinging for a few minutes after treatment.

Patients may experience inflammation/swelling, crusting/scabbing, blistering, erythema, heat/warmth around the treated area, or darkening of the lesion for a period of usually 7-14 days post-treatment and potentially up to 4 weeks depending on the area being treated, intensity of treatment and skin health prior to treatment. Lesions on the body generally have a longer healing time as those on the face. After the treatment, the treated area may look reddish, itch, and it is not uncommon for a blister to form withing a few hours. The blister can appear either clear or with a reddish or purplish shade. It is common to experience mild discomfort or pain in the treated area for the next few days following treatment. Blister Within the next couple of days, it is possible for a blister to develop as a result of cryosurgery. It is important not to intentionally open the blister, as it serves a purpose in allowing the separation and removal of the skin lesion from the surrounding healthy skin. The blister may contain clear or bloody fluid. It is normal for the treated area to be sensitive and cause discomfort for a few days. If needed, the client may need to revisit the clinic for drainage of the blister – again should we delete this, we would have people getting clients back to pop blisters, should be referring to their GP if this is required. In the event that the blister pops, it is advised to clean the site twice a day using a saline solution or tap water, or use an alcohol-free wipe, and gently dab or wipe the skin with it. Apply a smear of antiseptic cream. It may also be covered with a dressing/plaster. In general, it doesn’t require any special scare during the healing process. Gently wash the area once or twice a day, keeping it clean is important. The use of a bandage or dressing may only be necessary if the area is prone to rubbing against clothing or if there is a risk of easy injury. Swelling Swelling is a typical occurrence after cryosurgery, particularly around the eyes, forehead, and nose. If swelling does occur, there is no need for alarm. You can apply cool tap water-soaked towels to the affected area if required. Typically, the swelling will reduce over a period of 3-10 days. However, if the swollen area is both tender and swollen, it may indicate infection and should be reassessed by a healthcare professional. Eschar (scab) Eschar, also referred to as the “scab”, forms following cryosurgery. It is advisable to leave the large eschar undisturbed for as long as possible. It will naturally peel away on its own within 1-3 weeks, depending on the treated area once the underlying tissue has sufficiently healed. It is important not to pick at the scab, as it could disrupt the healing process and potentially lead to scarring. This natural protective barrier serves aiding in the healing process by maintaining a moist environment and facilitating the building of growth factors and formation of new granulation tissue. The liquid drainage from the eschar contains essential growth factors that contribute to advancing the healing process and promoting overall healing. In some cases, bleeding may occur after the procedure. If client experiences bleeding, advise them to gently apply firm and steady pressure using a dry cloth for 20 minutes or until the bleeding has stopped. If your lesion does not scab, it does not mean it was not successful, as all lesions respond differently and some only swell, before another session is required aprox 4 weeks later. Infection In the healing process, it is normal to observe a certain degree of redness and drainage as new blood vessels form. Some indicators of infection include continuous swelling, ongoing pain, excessive redness, significant warmth around the wound, and unusual drainage. Additionally, infected wounds tend to be overly tender to touch. For these symptoms, you should promptly notify a healthcare professional for evaluation and necessary treatment. You can usually have your next cryotherapy session at 4 weeks if your skin healing was not compromised. It is important to understand that for many weeks after, the area will likely still be settling, it can be pink, inflamed, and/or slightly uneven for up to 8–12 weeks and in some cases longer. We cannot guarantee the success of treatment or the outcome that you may have.

Typically, it leaves the least amount of scarring of any form of lesion removal because it causes the least damage to the connective tissues. Although rare, scarring is a possibility. Hypopigmented lesions will be noticeable until they darken with the new tanning. In some cases, at 4 weeks the area may still be settling, and it can be pink, inflammed and/or slightly uneven for up to 8–12 weeks and in some cases longer. Post-inflammatory hyperpigmentation (PIH) can happen after Cryotherapy, and it often fades over 8–12 weeks. Sometimes takes 3–6 months or in rare cases longer. We cannot guarantee the success of treatment or the outcome that you may have.

It is difficult to say how many sessions you may need, as there are varying factors involved.Often, 1-3 sessions will be enough.Larger, deeper, difficult, or some raised moles may need 2-3 sessions. In rarer cases, more.Some viral lesions may take several aggressive treatments; in particular, warts and verrucas often need multiple sessions. (or warts and verrucas, it is strongly recommended that you follow the preparation we advise before your appointment to prevent you from needing more treatments than necessary). Warts and verrucas are notoriously stubborn, and some strains of HPV are highly resistant to freezingWe can never guarantee the outcome of cryotherapy treatment, but generally get very good results with the majority of lesions.

For most lesions, cryotherapy is a permanent removal. Some lesions are harder to remove than others.

Both hypopigmentation and hyperpigmentation may occur after cryotherapy. Both generally last a few months, but can be longer-lasting. Permanent colour loss is more likely to occur in darker-skinned patients.

Initial healing depends on how deep the wound is, the lesion treated, your general health and age. Skins healing is complex, and although the initial healing is enough for the next cryotherapy session 4 weeks later, it is important to understand that for many weeks, the area will likely still be settling; it can be pink, inflamed, and/or slightly uneven. As the skin needs to go through A scab may form, your body’s immune system will start to protect the wound from infection. During the initial stage of wound healing, the following changes occur: A blister may form within the first 24 hours. The wound becomes slightly swollen, red or pink, and tender. Clear fluid may be observed oozing from the wound. This fluid aids in cleansing the area. Blood vessels in the vicinity of the wound dilate, allowing blood to deliver oxygen and nutrients vital for the healing process. White blood cells come into action, combating potential infections caused by germs and initiating the repair of the wound. This stage can be up to a week. Tissue growth and rebuilding. During the next 3 weeks, the body starts repairing broken blood vessels and new tissue develops. Red blood cells contribute to the creation of collagen, strong white fibres that serve as the foundation for new tissue formation. The wound gradually fills in with newly-formed tissue known as granulation tissue. New skin begins to form over this tissue. As the healing process progresses, the wound edges contract inward, resulting in a reduction in size. As healing advances. The process involves the maturation of new cells and can take several weeks to months, depending on the individual. During the first couple of weeks, you may experience itching in the area. Following the detachment of a scab, the area might appear stretched, red, and shiny. If a small scar forms, it will be smaller than the original wound. Over time, the scar will gradually fade and may even disappear entirely. This fading process can extend up to two years. It’s important to note that some scars may never fully fade away. Scars emerge because the newly formed tissue differs from the original tissue. Superficial injuries that only affect the top layer of the skin generally do not result in scarring. Typically, cryotherapy leaves the least amount of scarring of any form of lesion removal because it causes the least damage to the connective tissues. Although rare, scarring is a possibility. Remodelling phase - although skin would have healed enough for the next cryotherapy session around 4 weeks later, it is important to understand that for many weeks after, the area will likely still be settling, it can be pink, inflamed, and/or slightly uneven for 8–12 weeks and in some cases longer. Skin can stay pink and inflamed for weeks or months due to post-inflammatory erythema - a normal part of the healing process where increased blood flow to the site causes redness. This is a sign of the body's complex remodelling phase, during which new tissue is strengthened and repaired. The colour gradually fades during this long remodelling phase, which can last up to two years, and blood vessels return to normal. Hypopigmented lesions will be noticeable until they darken with the new tanning. Post-inflammatory hyperpigmentation (PIHP) can happen after Cryotherapy as part of the remodelling phase. It often fades over 8–12 weeks, and in some cases 3–6 months or longer. You can see images of the healing process on the main page. What else can affect healing: Generally, older adults tend to heal at a slower pace compared to younger individuals. Excessive alcohol consumption can impede the healing process, increase the risk of infection, and contribute to complications following surgical procedures. Blood thinners - if the blood is thin, the healing could be compromised. This makes the treatment healing uncertain. Specific medication Medicines such as corticosteroids, non-steroidal anti-inflammatory medicine can slow healing. Conditions such as arteriosclerosis (clogged arteries) or issues like varicose veins can results in inadequate blood circulation, hindering the healing process. Underlying health concerns may affect healing time. If you are concerned about the healing of your skin we always recommend you follow up with your GP or dermatologist for additional caution and medical advice. We cannot guarantee the success of treatment or the outcome that you may have.

There are no limitations on activity except to protect the area from damage or abrasion. Avoid swimming, saunas, steam rooms, sunbeds and excessive exercise causing sweating. Please follow the written aftercare advise you will be given.

Blistering is a common, normal response to cryotherapy treatment. If your blister pops or drains on its own, do not panic. Following these guidelines will protect the area, prevent infection, and ensure optimal healing with minimal scarring.1. Keep the Skin Flap IntactDo not peel or cut the loose skin: The deflated skin flap acts as a natural, sterile bandage for the raw tissue underneath.Tearing it away increases the risk of infection and can lead to permanent scarring.2. Clean and Protect the AreaWash gently: Clean the site daily with cool water and a mild, unscented soap. Pat dry gently with a clean towel; do not rub.Apply antiseptic: Apply a thin layer of an over-the-counter antiseptic cream (such as Savlon or Germolene) twice a day to keep the area clean.Dress if needed: If the area rubs against clothing or is prone to friction, cover it with a clean, breathable, non-stick plaster. Otherwise, you may leave it uncovered to air-dry.3. Avoid IrritantsFirst 24 hours: Do not apply makeup, scented lotions, perfumes, or deodorants to the treated area.First 72 hours: Avoid hot showers, baths, saunas, steam rooms, and swimming pools to protect the healing skin.4. Let Scabs Fall Off NaturallyAs the popped blister heals, it will dry out and form a dark crust or scab.This scab will naturally shed over the next 1 to 4 weeks (depending on the location and size of the treated lesion). Picking the scab prematurely will delay healing and increase scarring risks. When to Seek Medical AttentionWhile rare, infections can occur if a blister breaks. Please contact our clinic or your GP immediately if you notice:Redness, swelling, or warmth that is spreading away from the treatment site.Worsening or throbbing pain.Thick, yellow, or foul-smelling pus oozing from the area.A fever or general feeling of being unwell.

Follow-up should be scheduled usually at 4 week intervals to observe results, and for further sessions if required.

CryoPen® Therapy is a relatively low-risk treatment and side effects and complications are usually minimal. Some side effects may occur. These include: Pigment changes -both hypo pigmentation (lightening of the skin) and hyper pigmentation (darkening of the skin). Both generally last a few months, but can be longer lasting (see skin healing section on FAQ's). Nerve damage - though rare, damage to nerves is possible, particularly in areas where they lie closer to the surface of the skin, such as the fingers, the wrist, and the area behind the ear. Reports suggest this will disappear within several months. Shards of frozen humidity - the high pressure jet may cause minor shards of frozen humidity in the air blown away in a circle of approximately 30cm. They thaw the moment they touch healthy skin. Lesions on sites with coarse terminal hair - hair follicles are easily damaged by cryosurgery and permanent alopecia is not uncommon. Blisters - patients may experience blistering for a period of 7-14 days post-treatment and potentially up to 2-4 weeks depending on the area being treated, the intensity of the treatment, and skin health prior. Lesions on the body generally have a longer healing time compared to those on the face. Some people can have delayed healing, particularly if they have underlying health concerns. Cryotherapy is unlikely to leave a scar, but in rare cases, a scar can form, particularly with deeper lesions. The resulting scar is often a pale or white mark, sometimes slightly depressed or, very rarely, raised (hypertrophic or keloid), and is more likely to occur with deeper freeze treatments

You will be given full written aftercare on the day Following treatment, residual stinging, redness & slight swelling is normal. It is perfectly normal to experience these side effects, which can last for a few hours. The area needs to be kept as dry as possible during the initial healing. For the first 3 days, it is recommended to be careful whilst showering and to not wash the area, avoid swimming, saunas, steam rooms, sunbeds and excessive exercise causing sweating. Once scabbed , you can gently go back to your normal activities. Use a plaster to protect high bacterial areas during the day. If the area treated is in high-bacterial areas (like the underarms or groin), your practitioner may advise wearing a plaster during the day, and to wash the area in the evening and removing the plaster at night to allow the skin to breathe. It is normal for the lesion to turn darker or form a scab/crust. In the case of all lesions, over the next few days the area may turn darker and develop a crust on the surface. DO NOT pick this off. When it naturally falls away, you will see new skin which is a shiny pink/brown colour. This is not scarring. It will re-pigment over the following weeks and could take several months. There may be a slight difference in colour permanently. Permanent alopecia/hair loss can occur in a treated area which was previously covered with hair. Avoid picking at the treated area. Do not pick at the treated area at any time after treatment, otherwise the area will take longer to heal. If a scab is comes off accidentally, it will also take longer to heal, but you shoud still have the same outcome of a successful treatment. ​ If the scab comes off too early, check if the skin isn’t open. If it is open, this is an open wound and must be cared for to prevent infection. Put a plaster over the area to protect it and if the area becomes inflamed and produces pus, then it is infected. Use an antispetic lotion and see your GP. Wait until the scab has healed and comes off naturally before booking another session. If the small crust has not fallen off after four weeks, please wait until it has done so before booking another session. Skin can sometimes take several weeks and even months to regenerate. Do not use or apply any products unless advised or prescribed by your treatment provider. We do not recommend covering the area with a dressing or plaster unless we have advised you to do so. This applies to using any anti-septic creams unless there is the suspicion of an infection. If the area being treated is tanned, please note that healed skin will be lighter. Any depigmented areas post-procedure will eventually re-pigment as it matures. Protect the treated area and your skin with SPF. Once the scab has fallen off, please use a sunblock with SPF50 on any pigmentation removal until it has re-pigmented. If the area treated does not heal after 6 weeks, please contact your treatment provider.

Despite treating many lesions, we are not dermatologists and do not send them off for histology.Before treatment, all clients must provide written confirmation from an independent UK-licensed medical doctor (such as a GP or dermatologist) confirming that the lesion has been assessed as benign and is suitable for cosmetic removal. The letter must be dated within the previous 12 months at the time of treatment. If more than 12 months have passed since the assessment, an updated letter will be required before treatment can take place.Without the required documentation, treatment cannot proceed.Please note: Confirmation from a nurse or other non-medical healthcare professional cannot be accepted.You cannot have treatment without this confirmation. We keep this letter securely on your file.Applicable to the following:Seborrheic keratosis (brown warts, non-contagious) *Benign Moles *Skintags *Angiofibroma (fibrous papules) *Granuloma (inflamed nodules) *Dermatofibroma (benign fibrous skin growths) *Molluscum contagiosum (water warts) *Porokeratosis (dermatosis) *We can accept a screenshot of your patient record on the NHS App from the GP if it states the particular lesion in question is non-malignant and/or you are approved for further treatment.Please note we do not treat:Actinic keratosis (pre-cancerous skin lesions).Condyloma Acuminata (genital warts) MalasmaConfirmed Intradermal NaeviUnder the age of 14​Many clinics charge £100 as a consultation fee for the lesions to be checked and then charge for the treatment on top of this fee. Obtaining written confirmation from an NHS medical practitioner, it reduces your overall cost.If you don't want to wait for your GP we have a Registered Dermatology service which can check your lesion. The cost is £60 per lesion (£30 for any additional lesions), click here for more information.

The following are contraindications; therefore, treatment is not suitable:Under the age of 14​Pregnancy or breastfeedingCardiac DiseaseChemotherapy or Radiotherapy treatmentRaynaud diseaseImpaired wound healing, e.g. blood thinners, will require a GP note of approval (blood thinners can increase sensitivity to cold, and the skin can become thinner; the healing is compromised; this makes the treatment healing uncertain).Unstable diabetes, or type 1 diabetes, will require a GP note of approval. Pre-malignant/malignant lesions or any skin cancer elsewhereImpaired sensationImpaired circulationHypersensitivity to coldOpen woundRecent scar tissueProne to Keloid scarringThe following lesions are not suitableCondyloma Acuminata (genital warts) Actinic keratosis (pre-cancerous skin lesions)MalasmaConfirmed Intradermal NaeviAntihistamines - Please avoid taking them 2-3 days prior to your treatment unless medically prescribed. If it is taken for allergy reasons, seek professional medical advice before.

The following will require medical treatment: Redness, increased pain, yellow/green pus, or excessive clear fluid around the injury. These are signs of infection. Black edges around the injury. Bleeding at the injury site that will not stop after 10 minutes of direct pressure. Fever for more than 4 hours. Pain at the wound that will not go away, even after taking pain medicine.

If more than 1 treatment is required: 4 weekly for general lesions 2 weekly for viral lesions This allows for the initial healing to have taken place before a repeated treatment. Please read the section about the skins overall healing.

It depends on the lesion and your body. Some lesions are completly removed and others are reduced and/or flattened.

There are many different types of moles including: Common Moles, Junctional Melanocytic Naevi, Dermal Melanocytic Naevi, Dysplastic Naevi, Halo Naevi, and Congenital Naevi.Moles vary hugely and GP approval is required for all moles. Please note: Confirmed Intradermal Naevi are not suitable for cryotherapy.​​The characteristics of a normal mole will often be: SYMMETRY - Symmetrical, round or ovalBORDER - Well definedCOLOUR - Flesh coloured, light brown or dark brownDIAMETER - Usually less than ½ cmEVOLUTION - Stay fairly static with little change throughout the client’s lifeLOCATION - Most commonly found on sun-exposed areasUNIFORMITY - Most moles look similarSome things to look out for:ASYMMETRY – the two halves of the area differ in their shape. BORDER – the edges of the area may be irregular or blurred and sometimes show notches. COLOUR – this may be uneven. Different shades of black, brown and pink may be seen. DIAMETER - most melanomas are at least 6 mm in diameter.

Despite treating many lesions, we are not dermatologists, and we do not send lesions off to histology.Before treatment, all clients must provide written confirmation from an independent UK-licensed medical doctor (such as a GP or dermatologist) confirming that the lesion has been assessed as benign and is suitable for cosmetic removal. The letter must be dated within the previous 12 months at the time of treatment. If more than 12 months have passed since the assessment, an updated letter will be required before treatment can take place.Without the required documentation, treatment cannot proceed.You cannot have treatment without this confirmation. We keep this letter securely on your file.Applicable to the following:Seborrheic keratosis (brown warts, non-contagious) *Benign Moles *Skintags *Angiofibroma (fibrous papules) *Granuloma (inflamed nodules) *Dermatofibroma (benign fibrous skin growths) *Molluscum contagiosum (water warts) *Porokeratosis (dermatosis) *Please note we do not treat:Actinic keratosis (pre-cancerous skin lesions).Condyloma Acuminata (genital warts) MalasmaConfirmed Intradermal NaeviUnder the age of 14​We can accept a screenshot of your patient record on the NHS App from the GP if it states the particular lesion in question is non-malignant and/or you are approved for further treatment.Please note we do not treat Actinic keratosis (pre-cancerous skin lesions).

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Over the age of 14.