​Skin Rejuvenation Thanks to its ability to integrate into tissues, and boosts the production of elastin and collagen type I and III in your skin, in addition to regenerating your fat cells. This helps to improve both the firmness and elasticity of your skin. The treatment also enhances keratinocyte activity in your skin. Keratinocytes are a protein that helps to protect your skin. Enhancing their activity means that your skin barrier functions better so that your skin is stronger and in better health.

Fat Pad Remodelling The Profhilo Structura treatment is clinically proven to restore superficial fat to its original position, offering a very natural-looking, subtle lifting of the treated tissues.

Once injected via a cannular, Profhilo Structura activates the fat cells to behave more youthfully, triggering their natural regeneration and therefore improving the integrity of your fat pads and their ability to support the skin without the risk of looking ‘over done’.

Why are facial fat pads so important when it comes to looking rejuvenated and refreshed? As we age, our fat pads in the face shrink and descend, leading to volume loss, sagging skin, the appearance of cheek hollowness, and the formation of jowls.

Profhilo Structura targets these deeper layers to stimulate regeneration and improve their function, helping to prevent and improve early signs of this happening, whilst maintaining a completely natural look.

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Skin Hydration The hyaluronic acid in Profhilo Structura has extraordinary ability to retain water. The HA molecules attract and bind water, boosting hydration in the skin. Delivering hydration directly to your skin and surrounding tissue with this treatment supports the regeneration of both your fat pads and skin, whilst giving the tissue the healthy, plump skin associated with youth.

PROFHILO STUCTURA *

Ingredients: A bio-remodeler containing 90mg of Highly purified high & and low-molecular-weight hyaluronic acid.

Indication: A bio-remodeler designed to improve skin quality

Ideal for: Deeply hydrates the skin, stimulating the production of collagen and elastin for improved skin texture, elasticity, and a brighter, more youthful appearance.

Results: Immediate improvements in skin texture and hydration, with collagen improving over time.

Longevity: 6-9 months, sometimes 12 months.

RADIESSE

Ingredients: A biostimulator composed of calcium hydroxylapatite (CaHA) microspheres (which is naturally found in our skin).

Indication: Often preferred for skin tightening and improving skin quality.

Ideal for: Skin tightening and texture improvement in broader areas such as the neck, chest, and hands.

Results: Immediate improvement in skin texture and tightness, with results continuing to improve as collagen forms.

Longevity: 12-18 months.

SCULPTRA

Ingredients: A biostimulator made of poly-L-lactic acid (PLLA) microparticles.

Mechanism: The PLLA particles create a mild inflammatory response that attracts fibroblasts to produce new collagen, gradually restoring lost volum

Indication: Often more suitable for addressing volume loss and deep wrinkles.

Ideal for: Restoring significant facial volume and creating gradual, natural-looking changes in areas like the cheeks, temples, and jawline.

Results: Results are gradual, becoming visible over three to six months and are long-lasting, potentially up to two years.

Longevity: 24 months.

*Is Profhilo Structura the same as standard Profhilo?

No, Profhilo Structura is NEW.

Both use thermally-stabilised hyaluronic acid (HA) to improve your skin’s quality and firmness, but they differ in their approach, depth of action, and the specific concerns they target.

Profhilo Structura - Is a Bio-remodeller (bio-stimulator):

Focus is on improving the deeper layers of the face, specifically regenerating the fat pads.

The treatment zone is the adipose tissue (fat), targeted using a cannula.

Concentration of hyaluronic acid: 90mg in 2ml.

Ideal for those wanting to tackle deeper volume loss, providing a subtle, natural lift and helping to subtly restore youthful contours. Profhilo Structura is better suited for those who are starting to experience more advanced signs of ageing, including volume loss and early skin sagging.

2 treatment sessions, approximately 1 month apart.

Results last around 6-12 months.

Profhilo (standard) - is a Skin Booster (click here):

Focus is improving surface level skin quality.

The treatment zone is the skin’s dermis, targeted using a needle.

Concentration of hyaluronic acid: 64mg in 2ml.

Ideal for individuals looking to improve skin texture, tone, and elasticity. It addresses fine lines and wrinkles, improves overall skin hydration, and gives the skin a more youthful, glowing appearance without adding volume or altering facial contours.

2 treatment sessions, approximately 1 month apart.

Results last up to 6 months.

Bio-Stimulators are specifically designed to remodel your deep facial-tissue structures, such as your collagen and facial fat pads. It is a good standalone therapy for those requiring deeper firmness and for those who do not want or require dermal filler to replace volume lost from ageing.

Bio-Stimulators may be a good treatment option for you if:

• You’d like to improve signs of facial ageing without drastically changing your appearance.

• You’re experiencing hollowness or sunken cheeks and want to help restore a lifted, natural contour.

• You’re noticing early jowling and you’d like to restore structure to your jawline.

• You feel that you’ve lost facial volume; perhaps your cheeks have lost some of their definition or your mid-face is starting to look flatter.

• Skin sagging is starting to become apparent.

• You are noticing moderate wrinkles, particularly nose-to-mouth lines and marionette lines.

• You would like to boost skin hydration.

• You’re noticing skin changes because of the perimenopause and menopause. Women experience accelerated signs of ageing at this stage due to hormonal changes and can often benefit from deeper tissue remodeling, should they wish.

• You are considering preventative skin treatments. Those in their late 30s and early 40s may use Bio-Stimulators to help them maintain their facial structure and skin integrity and help to delay more advanced signs of ageing.

Placement depends on concern:

Sinkers: Individuals with a predominantly hollow or sunken appearance due to volume depletion in the cheek area.

Saggers: Individuals with volume loss, sagging skin and jowls. The outcome is unique and natural to you because it’s YOUR collagen that we’re regenerating; we're not adding anything else to create volume and structure-this is all you. When you think about Bio-Stimulators, think more structure and a natural lift.

Bio-Stimulators are also an ideal option for patients looking for a more natural alternative to traditional dermal fillers, as it offers regenerative benefits with minimal risk and no downtime. It is designed to restore the superficial fat layer and improve overall skin quality, making it firmer and more hydrated​. But of course - you can have both!

You would have already completed the medical form at the time of booking, so straight after the consultation, you can have the treatment.

Profhilo® Structura

Noticeable: Subtle improvements in skin hydration, elasticity, and smoothness can appear as early as 2–4 weeks.

Optimal: After 2 treatment sessions, around 6–8 weeks after the second session.

Duration: Effects last 6–12 months, depending on skin condition and lifestyle.

Radiesse® Hyperdilute (CaHA)

Initial: Slight lift/plumping from gel (temporary, usually subsides within a few days).

Noticeable: 4–6 weeks as collagen begins to form.

Optimal: Full affect can start to be seen around 2–3 months after treatment, however stability is achieved at 9 months.

Duration: Effects typically last 12–18 months.

Sculptra® (PLLA)

Initial: Minimal immediate change (sometimes slight swelling from injection fluid).

Noticeable: 6–8 weeks after the first session, as collagen begins to form.

Optimal: Full effect can start to be seen after 2–3 sessions, usually around 3–6 months.

Duration: Results can last up to 2 years or more, depending on age, lifestyle, and metabolism.

We recommend 2 – 3 treatments performed 1-2 months apart for optimal results. The number you will need will depend on your overall skin health, amount of skin laxity and volume loss.

How long does it last?

Profhilo Structura 6-9 months (sometimes 12 months)

Radiesse 12-18 months.

Sculptra up to 2 years and sometimes longer

Rule of thumb guidance for Sculptra is that you need 1 vial for every decade of life, so if you are age 42 you may need 4 vials spread accross 2-3 treatments, and if you are age 63 you may need 6 vials spread acrooss 2-3 treatments.

Some patients don't want to wait for 2 years until they have it again, and opt for long-term maintenance, by having one treatment every 6mths for Profhilo Structura / one treatment every 12 months for Radiesse and Sculptra (or when you begin to see the treatment’s effects wearing away). This is good for keeping up with optimum results.

Tip: Alternating Bio-stimulators with Skin Boosters (6 monthly), Exosomes (6 monthly), and Polynucleotides (6 monthly) will further enhance all aspects of skin ageing and skin rejuvenation.

Biostimulators stimulate the body to naturally produce new collagen and elastin, improving skin firmness and elasticity over time, while dermal fillers primarily provide immediate, but temporary volume and shape by physically filling in wrinkles and folds.

Biostimulator results are more gradual and subtle, with longer-lasting effects, whereas filler results are immediate but typically shorter-lived, requiring touch-ups.

If you are allergic to hyaluronidase (filler dissolver) and don't want to risk having fillers, this is a great alternative!

Bio-Stimulators can be used on the face, neck, decolletage and back of hands, with the exception of Profhilo Structura, which is only suitable for the face.

You will usually need 2 treatments spaced 4-6 weeks apart. So work backwards , allowing time for healing if you have a special event.

As with many aesthetic treatments, there is always a risk of bruising, so please ensure that you do not have any important special events such as holidays, weddings and parties in the week or so after your treatment. Bruising can last up to 2 weeks.

Please avoid any dental treatments, facials, massage and other treatments for at least 2 weeks after treatment.

The injections are carried out using a cannula, which means less injection points, it can feel a little uncomfortable but is generally very well tolerated.

After the treatment, you may experience some tenderness for the first 24- 72 hours.

Not suitable if:

You are under 18 years of age.

You have a known hypersensitivity to hyaluronic acid.

You have an active infection or inflammation near the intended injection site.

You think you could be pregnant, are pregnant, or are lactating or breastfeeding. There are no adequate and well-controlled studies of Profhilo STRUCTURA in pregnant or nursing women; therefore, safety cannot be guaranteed.

To ensure the safest experience and the best possible results, please follow these recommendations before your appointment:

Medications & Supplements – 3 days prior to treatment avoid blood-thinning medications and supplements (unless prescribed by your doctor): aspirin, ibuprofen, naproxen, vitamin E, fish oils, ginkgo, garlic, St John’s Wort. Do not stop prescription medication without first consulting your prescribing doctor. If you are prone to bruising, taking arnica orally for a few days prior to treatment may lessen the risk

2 weeks before/after don't have a COVID-19, Influenza vaccincation, or antibiotics .

Alcohol & Lifestyle - Avoid alcohol for 24 hours before treatment (it increases the risk of bruising). Reduce caffeine and very salty foods on the day of treatment to minimise swelling. Stay well-hydrated in the days leading up to your appointment and eat a light meal before your appointment.

Avoid heavy exercise 24 hrs prior to your appointment.

Skincare - Avoid active skin irritation (eczema, rashes, cold sores, sunburn).

Do not wear makeup to the appointment (mascara is ok).

Other Treatments - 1 week before avoid using active skincare such as retinoids (retinol, tretinoin, retinoic acid) and strong acids such as glycolic, AHA/BHA (can cause irritation & inflammation).

2 weeks prior don't have toxin (Botox), standard laser, dermaplaning, dermal fillers, electrolysis, depilatory creams, waxing on the area.

4 weeks prior do not have microneedling, dermabrasion, deep chemical peels, PDO threads, tattoos, ablative skin treatments ie Co2 fractional laser (skin must be fully healed before treatment).

Health Considerations - Inform us of any changes to your medical history, medications, or allergies since your last visit. Treatment is not recommended if you are pregnant, breastfeeding, have active infections, or certain autoimmune conditions.

Planning Your Appointment - Mild swelling, redness, or bruising is common — plan your appointment with this in mind if you have social events coming up. Allow at least 2–3 weeks before important occasions.

Avoid Dental Work - Avoid dental procedures (including routine cleanings) for 2 weeks before and after, as these can increase the risk of infection. Major dental work should be avoided 4 weeks before and after.

To ensure the best possible results from your treatment and to minimise any risks or side effects, please follow the aftercare instructions below:

Immediately After Treatment

• You may experience mild swelling, redness, or small bumps at the injection sites. This is completely normal and should subside within 24–72 hours.

• Avoid touching the treated area for at least 12 hours to reduce the risk of irritation or infection.

• Refrain from applying makeup for at least 12 hours, especially on or around the injection sites.

• The treated area will feel slightly tender to the touch or with extreme facial expression. If bruising occurs, it will typically resolve over 5-10 days. Applying Arnica gel or bruise creams may help for a quicker recovery.

• If needed, you can gently apply a cold compress (not directly on the skin) to reduce swelling or discomfort.

• The area can be gently washed with a gentle cleanser or micellar water in the evening.

Follow the 555 massage rule if you have had Radiesse or Sculptra*

First 24–48 Hours

• Avoid alcohol, caffeine, aspirin or anti-inflammatory medications, unless prescribed — these can increase the risk of bruising.

• Do not engage in strenuous exercise, swimming, or anything that causes excessive sweating.

• Avoid hot environments such as saunas, steam rooms, hot yoga, or very hot baths/showers.

• Sleep with your head slightly elevated for the first night if possible, to reduce any minor swelling.

First 2 weeks

• Avoid extended sun and UV exposure (including sun beds) and temperatures below 0 degrees for two weeks.

• Avoid heat treatments such as sauna and steam for two weeks.

Skincare & Hygiene

• Continue your usual gentle skincare routine but avoid any exfoliating products, acids (e.g. glycolic/salicylic), retinoids or vitamin C serums for 48–72 hours.

• Keep the area clean and moisturised to support skin healing, ideally a hyaluronic acid based skincare product.

• Apply a broad-spectrum SPF 30 or higher daily to protect your skin.

* 5-5-5 Massage rule - For Radiesse and Sculptra only

This step is very important as biostimulators cannot be dissolved if nodules form- massage the treated area for 5 minutes, 5 times a day, for 5 consecutive days after the injection, to ensure the biostimulator disperses evenly, promotes collagen stimulation, and helps prevent the formation of lumps or nodules. This aftercare is crucial for maximising the treatment's effectiveness and achieving smooth, natural-looking results

What to Expect Over Time

• You may not see immediate visible changes. Results will develop gradually over the coming weeks, as your skin produces more collagen and elastin:

Profhilo - optimal results are typically seen around 2 weeks after the second treatment.

Radiesse - you may notice firmer, smoother skin within 4–6 weeks. Best results usually seen around 2–3 months.

Sculptra - you may start to see results 6–8 weeks after the first session. Most patients see the biggest difference after the 2nd or 3rd session, often around 3–6 months total.

For best long-term maintenance, we recommend one treatment every 6mths for Profhilo Structura, and 12 monthly for Radiesse and Sculptra, or when you begin to see the treatment’s effects wearing away.

Combine with Skin Boosters, Exosomes or Polynucleotides to further enhance rejuvenation.

When to Contact Us

Please get in touch if you experience any of the following:

• Severe pain, increasing redness or swelling after 3 days

• Signs of infection (heat, pus, or fever)

• Any unusual symptoms or concerns following your treatment

No, the treatment will not affect facial movement. It targets the deep dermis and fat layer rather than the muscles, meaning your facial expressions will remain natural and unaffected.

Profhilo Structura

Radiesse

Sculptra